Polynucleotides are the science-backed injectable everyone’s talking about, and now available at Inside Aesthetics. But what do polynucleotides do to the skin, and why are they different from other injectables?
In this blog, we break down how polynucleotides work, the benefits they offer, and who they’re suitable for. If you’re looking for an under eye treatment that improves skin health at a deeper level, this could be the one.
What are Polynucleotides?
Polynucleotides are natural, biocompatible molecules derived from highly purified salmon DNA. They work by giving your skin’s less active cells the tools they need to regenerate, repair and behave more like younger skin.
As we age, our skin loses collagen, elastin and hydration. Polynucleotides help to reactivate skin regeneration by stimulating fibroblasts; the cells responsible for producing these vital proteins.
In other words, they don’t just mask the signs of ageing. They target the cause.
What Do Polynucleotides Do to the Skin?
1. Improve Skin Elasticity and Firmness
By stimulating collagen and elastin production, polynucleotides help improve the firmness and flexibility of the skin. This can lead to a visible reduction in fine lines, wrinkles and under eye hollows.
2. Hydrate and Refresh Tired Skin
While polynucleotides are not designed to work as injectable moisturisers (like Profhilo), they can improve the skin’s ability to retain water. This leads to a more hydrated, healthy and radiant look, especially around the eyes.
3. Soothe and Repair Damaged Skin
Thanks to their anti-inflammatory properties, polynucleotides also support skin repair and are suitable for treating:
- Eye bags and dark circles
- Rosacea
- Acne scarring
- Sun-damaged or dry skin
How Are Polynucleotides Different to Other Injectables?
Unlike Botox, polynucleotides are not a toxin and do not freeze facial muscles or alter your expression. And unlike dermal fillers, they do not add volume.
Instead, they focus on cellular regeneration, helping your skin to rebuild itself from within. This makes them a great choice for people looking for natural-looking results and long-term skin health benefits.
Polynucleotides can also complement other treatments such as Hydrafacial or Microneedling for a complete skin rejuvenation approach.
Where Are Polynucleotides Injected?
At Inside Aesthetics, we use polynucleotides under and around the eye area, one of the first places to show signs of ageing. When injected, they promote cell turnover, improve texture, and help smooth out wrinkles and puffiness.
Treatments typically take 15 to 30 minutes with minimal downtime. You can return to your usual routine right after your appointment.
How Many Treatments Will I Need?
For best results, we recommend a course of 2 to 3 treatments, spaced 3 to 4 weeks apart. Most clients then return for a maintenance session every 3 to 4 months to keep their results looking fresh.
Results are gradual and natural, with visible improvements often showing within a few weeks of starting treatment. Full results are usually seen within 3 months.
Who Can Benefit from Polynucleotides?
Polynucleotides are suitable for a wide range of skin concerns, including:
- Wrinkles, fine lines and sunken skin
- Dark circles or puffiness under the eyes
- Dry or dehydrated skin
- Rosacea and acne scarring
- General loss of elasticity and glow
If you’re looking for a gentle, regenerative treatment that restores your skin’s natural bounce and brightness, polynucleotides are worth exploring.
Why Choose Inside Aesthetics?
We pride ourselves on delivering personalised, expert-led skin treatments that are tailored to you. Our team has undergone advanced training in polynucleotide injectables, and we’re proud to be among the first clinics to offer this cutting-edge treatment in the area.
You’ll receive a complimentary consultation to assess your needs, answer your questions, and build a bespoke plan that delivers real results.
Ready to Refresh Your Skin?
If you’ve been wondering what polynucleotides do to the skin, the answer is simple – they help your skin function, feel and look like younger skin again.
Whether you want to target the under eye area, reduce early signs of ageing or simply boost your skin’s health, Inside Aesthetics is here to help.




